‘Nanozyme’ therapy prevents harmful dental plaque build-up

Pairing iron oxide nanoparticles with hydrogen peroxide results in a precisely targeted treatment for killing harmful oral bacteria, breaking down dental plaque, and even diagnosing harmful oral biofilms, according to a new study. Credit: Courtesy of the study authors

A growing body of evidence points to a link between iron-deficiency anemia and severe tooth decay. Whether the connection is correlative or causative is unknown, though both conditions are associated with poor diets and are more common in people living in impoverished environments and with underlying medical conditions.

Now, research from the University of Pennsylvania, in collaboration with Indiana University, suggests that an FDA-approved therapy for iron-deficiency anemia also holds promise for treating, preventing, and even diagnosing dental decay. The therapeutic, a combination of an iron-oxide nanoparticle-containing solution called ferumoxytol and hydrogen peroxide, was applied to real tooth enamel placed in a denture-like appliance and worn by the study subjects.

The study, published in the journal Nano Letters, found that a twice daily application of ferumoxytol, which activated hydrogen peroxide contained in a follow-up rinse, significantly reduced the buildup of harmful dental plaque and had a targeted effect on the bacteria largely responsible for tooth decay. These types of nanoparticles with enzyme-like properties are sometimes known as “nanozymes” and are increasingly being explored for their potential in biomedical and environmental applications.

“We found that this approach is both precise and effective,” says Hyun (Michel) Koo, a professor in the University of Pennsylvania School of Dental Medicine. “It disrupts biofilms, particularly those formed by Streptococcus mutans, which cause caries, and it also reduced the extent of enamel decay. This is the first study we know of done in a clinical setting that demonstrates the therapeutic value of nanozymes against an infectious disease.”

The work is an extension of a 2018 paper published in Nature Communications, in which Koo and colleagues, including David Cormode of Penn’s Perelman School of Medicine, showed that the iron oxide nanoparticle-hydrogen peroxide treatment could prevent biofilm accumulation and tooth-decay in an experimental model and an animal model.

In the current work, the scientists wanted to take the next logical step, working in humans. In a randomized study, they had 15 participants use a removable, denture-like device with real tooth enamel attached, a method developed and extensively tested by Domenick T. Zero of Indiana University, a co-corresponding author on the current paper.

The study participants applied a sugar-containing solution to the appliance four times a day, mimicking high-sugar meals and snacks consumed in the course of daily life. Participants were asked not to brush the enamel specimens but instead to rinse the appliance twice a day. Participants were divided into three groups, with one using the ferumoxytol then the hydrogen peroxide rinse, one with a solution that provides the inactive ingredients in ferumoxytol, and a third with water alone.

After 14 days, the researchers analyzed the biofilms that accumulated on the enamel specimens. They found the experimental treatment potently reduced the growth of biofilms containing S.

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Oral Therapy For Ringworm

Medication
For some people, discovering the precise acid reflux disease prescription medications is something that turns out to be quite simple, but for others, there could also be some trial and error concerned. Many become hooked on prescription drugs resembling cough syrups, anti-allergic medication, antacids, pain relievers or tonics. I am referring to the handfuls of various prescription psychiatric medications. Individuals vary enormously of their sensitivity to drugs.

On this list of medications for ADHD, each of these drugs has the potential for long run drug dependence. Here are five of the most typical and most used medications for acid reflux disease. Uncomfortable side effects embody constipation, dizziness, headache, nausea, and more not often low blood strain, heart failure or arrhythmias.

A meta analysis of all studies mixed showed that remedy with calcium channel blockers did not enhance mortality more than a placebo, though ACE inhibitors did (BPLTTC. Calcium channel blockers act on the lining of the blood vessels. These medication appear to trigger more coronary heart problems than conventional diuretic therapies.

By blocking the calcium channels, these medicine trigger the vessels to loosen up, consequently blood pressure goes down. Using the same doctor with experience with Autism and combining medications would possibly make the seek for a doctor a bit extra difficult.

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Prescription drug labeling provides a affected person information about what drug she or he is taking, the meant dosage, when the drug should be taken, the potential negative effects of the drug, and the potential interactions the drug may have with other drugs. Strattera – adverse results may embrace stomach problems, complications, loss of urge for food (described within the literature as anorexia!) and dizziness. Furthermore, antacids are also mild enough for most individuals, they usually don’t include lots of the unwanted side effects which can be commonly associated with other prescription heartburn medications.

This similar doctor will maintain prescribing this medication too all patients that have the same symptoms as a result of it worked the primary time. Many types of blood stress medications, including alpha-blockers, beta-blockers, and diuretics, reduce zinc and testosterone ranges, damage libido, and adversely have an effect on nerve functioning.

Medication Therapy Of Gastroesophageal Reflux Disease (GERD)

Medication
The medication for Graves Illness includes the taking in of antithyroid medication. Twenty cancer patients discovered that commonplace anti-nausea medications were not serving to and were randomized into placebo or THC. Which is why most docs will in all probability advocate SSRIs to you since this antidepressant, though new, have cured many sufferers with much less negative effects.

In the International Nifedipine GITS Study: Intervention as a Objective in Hypertension Remedy (PERCEPTION) research (Brown … Read More...

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Oral Therapy For Ringworm

Medication
With so many news studies about Michael Jackson’s dying, what have we discovered? Prevacid (generic title-lansoprazole): That is one other of the PPI medicine, and it helps retard acid production whereas permitting the broken tissues within the esophagus to correctly heal. Conventional medicine recommends quite a few totally different natural medications for a variety of circumstances, together with high blood pressure.

High blood pressure is quite common to young and outdated folks alike; nevertheless, medical doctors say, it may be managed. Alpha-blocker drugs assist in the right circulation of the blood by decreasing the nerve impulses to the blood vessels. There are various the reason why individuals flip to antacids to cease heartburn, the most obvious of which is that it is readily available in any pharmacy.

The most typical medicine to battle these symptoms are the medications finasteride and dutasteride, 5-alpha-reductase inhibitors, designed to manage androgen manufacturing which leads to non-cancerous progress of the prostate gland. Health crèmes are nutrient-rich merchandise which will help to protect the penis and the male reproductive system from damage from prescription medications.

Diuretics in comparison with calcium channel blockers had 6{cbae21074713859432fc936988a1df767d615a4d39f985b4de503c3266254961} fewer heart problems occasions and 26{cbae21074713859432fc936988a1df767d615a4d39f985b4de503c3266254961} less heart failure; compared to ACE inhibitors there was 12{cbae21074713859432fc936988a1df767d615a4d39f985b4de503c3266254961} less heart failure, 6{cbae21074713859432fc936988a1df767d615a4d39f985b4de503c3266254961} less heart problems occasions and 14{cbae21074713859432fc936988a1df767d615a4d39f985b4de503c3266254961} much less stroke.

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Medication

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Clearly it’s not sensible for males to easily cease taking prescription medications, however in many instances the detrimental impression upon the male organ can be lowered.
Medication
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Medication modifications or adjustments may cause a stable medical situation to be categorized as a pre-present medical condition under many travel insurance coverage companies plans. Such a medication is a PPI, which stands for ‘proton pump inhibitor.’ Which means the medication is supposed to lessen the amount of acid the abdomen produces. Ritalin – a stimulant that has the next potential unwanted effects: decreased urge for food, irritability and despair, headaches, abdomen upset, issue sleeping, fidgeting, nervousness, tics, seizures, heart issues and even sudden death.

Sadly many, even most of these medicines, have, in addition to their meant objective, what we all know as “negative unwanted effects.” They might make us really feel so much better by relieving the condition from the unique drawback, however then typically unleash foreign substances into the physique that can trigger new issues.

Medication Remedy Of Gastroesophageal Reflux Disease (GERD)

Medication
In line with a recent research in California, USA the extra prescription drugs imbibed into the body, the better the danger of penis well being issues corresponding to impotence and erectile dysfunction. On this checklist of medications for ADHD, every of those drugs has the potential for long term drug dependence. Listed here are five of the most typical and most used medications for acid reflux disease. Unwanted side effects embrace constipation, dizziness, headache, nausea, and extra hardly ever low blood strain, heart … Read More...

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